Publications

2019

Ardila-Fierro KJ, Pich A, Spehr M, Hernández JG, Bolm C (2019) Synthesis of acylglycerol derivatives by mechanochemistry. Beilstein Journal of Organic Chemistry, 15, 811–817. DOI: 10.3762/bjoc.15.78

Marom K, Horesh N, Abu-Snieneh A, Dafni A, Paul R, Fleck D, Spehr M, Ben-Shau Yl (2019) The vomeronasal system can mediate novel stimulus response pairings. Cell
Reports
. DOI:10.1016/j.celrep.2019.03.042

Gretenkord S, Kostka JK, Hartung H, Watznauer K, Fleck D, Minier-Toribio A, Spehr M, Hanganu-Opatz IL (2019) Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice. PLoS Biology 17: e2006994. DOI: 10.1371/journal.pbio.2006994

2018

Wong WM, Nagel M, Hernandez-Clavijo A, Pifferi S, Menini A§ , Spehr M§, Meeks JP§ (2018) Sensory Adaptation to Chemical Cues by Vomeronasal Sensory Neurons. eNeuro. DOI: 10.1523/ENEURO.0223-18.2018
§shared senior authorship

Mundt N, Spehr M, Lishko PV (2018) TRPV4 is the temperature-sensitive ion channel of human sperm. eLIFE 7: e35853. DOI: 10.7554/eLife.35853

Mohrhardt J, Nagel M, Fleck D, Ben-Shaul Y, Spehr M (2018) Signal detection and coding in the accessory olfactory system. Chemical Senses 43: 667-695. DOI: 10.1093/chemse/bjy061

Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A. ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation. Scientific Reports 8: 1431. DOI: 10.1038/s41598-018-19624-3

Pelz T, Drose DR, Fleck D, Henkel B, Ackels T, Spehr M, Neuhaus EM (2018) An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase. PLOS ONE 13:e0191219. DOI: 10.1371/journal.pone.0191219

2017

Unger J, Mansour M, Kopazka M, Gronloh N, Spehr M, Merhof D. (2017) An Unsupervised Learning Approach for Tracking Mice in an Enclosed Area. BMC Bioinformatics 18(1): 272. DOI: 10.1186/s12859-017-1681-1

Wallbrecher R⁠, Ackels T, Olea⁠ RA, Klein MJ, Caillon⁠ L, Schiller⁠ J, Bove-Geurts PH, van Kuppevelt⁠ TH, Ulrich⁠ AS, Spehr⁠ M, Adjobo-Hermans⁠ MJW, Brock R. (2017) Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity. Journal of Controlled Release 256: 68–78.DOI: 10.1016/j.jconrel.2017.04.013

Henkel B, Bintig W, Bhat S, Spehr M, Neuhaus EM (2016) NHERF1 in Microvilli of Vomeronasal Sensory Neurons. Chemical Senses 42: 25-35.144. DOI: 10.1093/chemse/bjw094

2016

Gorin M, Tsitoura C, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O’Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M (2016) Interdependent conductances drive infra-slow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons. The Journal of Neuroscience 36: 3127-3144. DOI: 10.1523/JNEUROSCI.2520-15.2016

Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M (2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271. DOI: 10.1085/jgp.201611636

2015

Cichy A, Ackels T, Tsitoura C, Kahan A, Gronloh N, Söchtig M, Engelhardt CH, Ben-Shaul Y, Müller F, Spehr J, Spehr M (2015) Extracellular pH regulates excitability of vomeronasal sensory neurons. The Journal of Neuroscience 35: 4025-4039. DOI: 10.1523/JNEUROSCI.2593-14.2015

Bitzenhofer SH, Sieben K, Siebert KD, Spehr M, Hanganu-Opatz IL (2015) Oscillatory activity in developing prefrontal networks results from theta-gamma modulated synaptic inputs. Cell Reports 3: 486-497. DOI: 10.1016/j.celrep.2015.03.031

Henkel B, Drose D, Ackels T, Oberland S, Spehr M, Neuhaus EM (2014) Coexpression of Anoctamins in cilia of olfactory sensory neurons. Chemical Senses 40: 73-87. DOI: 10.1093/chemse/bju061

Oberland S, Ackels T, Gaab S, Pelz T, Spehr J, Spehr M, Neuhaus EM (2015) CD36 is involved in oleic acid detection by the murine olfactory system. Frontiers in Cellular Neuroscience9: 366. DOI: 10.3389/fncel.2015.00366

2014

Kaur AW, Ackels T, Kuo T, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M and Stowers L (2014) Murine Pheromone Proteins Constitute a Context-Dependent Combinatorial Code Governing Multiple Social Behaviors. Cell 157: 676-88. DOI: 10.1016/j.cell.2014.02.025

Ackels T, von der Weid B, Rodriguez I and Spehr M (2014)
Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ. Frontiers in Neuroanatomy. DOI: 10.3389/fnana.2014.00134

2012 – 2013

Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD (2013) A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system. Nature, DOI: 10.1038/nature12579

Dietzel E, Wessling J, Floehr J, Schäfer C, Ensslen S, Denecke B, Rösing B, Neulen J, Veitinger T, Spehr M, Tropartz T, Tolba R, Renne R, Egert A, Schorle H, Gottenbusch Y, Hildebrand A, Yiallouros I, Stöcker W, Weiskirchen R, Jahnen-Dechent W (2013) Fetuin-B, a liver-derived plasma protein is essential for fertilization. Developmental Cell 25, 106–112. DOI: 10.1016/j.devcel.2013.03.001

Fluegge D, Moeller LM, Cichy A, Gorin M, Weth A, Veitinger S, Cainarca S, Lohmer S, Corrazza S, Neuhaus EM, Baumgartner W, Spehr J, Spehr M (2012) Mitochondrial Ca Mobilization is a key element in olfactory signaling. Nature Neuroscience 15: 754-762. DOI: 10.1038/nn.3074

2011

Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M, Neuhaus EM (2011) G-protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. Journal of Biological Chemistry 286: 13184-13192. DOI: 10.1074/jbc.M110.183525

Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK§, Spehr M§, Hatt H§. (2011) Chemosensory
Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. Journal of Biological Chemistry 286: 17311-17325. DOI: 10.1074/jbc.M110.211524
§shared senior authorship

Ferrero DM, Lemon JK, FlueggeD, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. Proceedings of the National Academy of Sciences 108: 11235-11240. DOI: 10.1073/pnas.1103317108

Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corrazza S, Spehr J, Neuhaus EM, Spehr M (2011) Mitochondrial Ca Mobilization in Purinergic Mouse Sertoli Cell Signaling. The Journal of Physiology589: 5033–5055. DOI: 10.1113/jphysiol.2011.216309

2009 – 2010

Hagendorf S, Fluegge D, Engelhardt C, Spehr M (2009). Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. The Journal of Neuroscience 29: 206-221. DOI: 10.1523/JNEUROSCI.3656-08.2009

Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders-Zufall T, Zufall F (2009) Ca2+-calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. The Journal of Neuroscience 29:2125-2135. DOI: 10.1523/JNEUROSCI.5416-08.2009

Spehr M and Munger SD (2009) Olfactory receptors: GPCRs and beyond. The Journal of Neurochemistry 109: 1570-1583. DOI: 10.1111/j.1471-4159.2009.06085.x

Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009) Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459: 574-577. DOI: 10.1038/nature08029

2006 – 2008

Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006) β-arrestin2-mediated internalization of mammalian odorant receptors. The Journal of Neuroscience 26: 9902-9912. DOI: 10.1523/JNEUROSCI.2897-06.2006

Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F (2006) Essential role of the main olfactory system in social recognition of MHC class I peptides. The Journal of Neuroscience 26: 1961-1970. DOI: 10.1523/JNEUROSCI.4939-05.2006

Kelliher KR§, Spehr M§, Leinders-Zufall T, Zufall F (2006) Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. European Journal of Neuroscience 23: 3385-3390. DOI: 10.1111/j.1460-9568.2006.04866.x
§ authors contributed equally

2001 – 2005

Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-773. DOI: 10.1016/S0896-6273(02)00610-4

Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. The Journal of Neuroscience 22: 8429-8437. DOI: 10.1523/JNEUROSCI.22-19-08429.2002

Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058. DOI: 10.1126/science.1080376

Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. Journal of Biological Chemistry 279: 40194-40203. DOI: 10.1074/jbc.M403913200

Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H (2004) Dual capacity of a human olfactory receptor. Current Biology 14: 832-833. DOI: 10.1016/j.cub.2004.09.034

Theme by Anders Norén