Dr. David Fleck

Position:
Post-Doc

Seit:
April 2011

Forschungsfelder:
Physiologie der Testikularzellen

Methoden:
Elektrophysiologie, Ca2+-Imaging, CLARITY, Zellkultur, STED Microskopie

Kontakt:
d.fleck@sensorik.rwth-aachen.de
Tel.: +49 (0)241 / 80-20805
ResearchGate

https://3dsr.rwth-aachen.de/en/home/

Publikationen:

Fleck D, Kenzler L, Mundt N, Strauch M, Uesaka N, Moosmann R, Bruentgens F, Missel A, Mayerhofer A, Merhof D, Spehr J, Spehr M (2021) ATP activation of peritubular cells drives testicular sperm transport. eLIFE 10:e62885 DOI: 10.7554/eLife.62885
Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ (2019) Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis. Kidney International 96: 505-516 DOI: 10.1016/j.kint.2019.02.034
Zhang Y, Vargas Cifuentes L, Wright K, Bhattarai J, Mohrhardt J, Fleck D, Janke E, Jiang C, Cranfill S, Goldstein N, chreck M, Moberly A, Yu Y, Arenkiel B, Betley J, Luo W, Stegmaier J, Wesson D, Spehr M, Fuccillo M, Ma M (2021) Ventral striatal islands of Calleja neurons control grooming in mice. Nature Neuroscience 24 (12). DOI: 10.1038/s41593-021-00952-z
Marom K, Horesh N, Abu-Snieneh A, Dafni A, Paul R, Fleck D, Spehr M, Ben-Shau Yl (2019) The vomeronasal system can mediate novel stimulus response pairings. Cell Reports. DOI:10.1016/j.celrep.2019.03.042
Gretenkord S, Kostka JK, Hartung H, Watznauer K, Fleck D, Minier-Toribio A, Spehr M, Hanganu-Opatz IL (2019) Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice. PLoS Biology 17: e2006994. DOI: 10.1371/journal.pbio.2006994
Mohrhardt J, Nagel M, Fleck D, Ben-Shaul Y, Spehr M (2018) Signal detection and coding in the accessory olfactory system. Chemical Senses 43: 667-695. DOI: 10.1093/chemse/bjy061
Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A (2018) ATP-mediated events in peritubular cells contribute to sterile testicular inflammation. Scientific Reports 8: 1431. DOI: 10.1038/s41598-018-19624-3
Pelz T, Drose DR, Fleck D, Henkel B, Ackels T, Spehr M, Neuhaus EM (2018) An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase. PLOS ONE13:e0191219. DOI: 10.1371/journal.pone.0191219
Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R (2017) Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell 20: 785-800. DOI: 10.1016/j.stem.2017.03.008
Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M (2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271. DOI: 10.1085/jgp.201611636
Gamper I, Fleck D, Barlin M, Spehr M, El Sayad S, Kleine H, Maxeiner S, Schalla C, Aydin G, Hoss M, Litchfield DW, Lüscher B, Zenke M, Sechi A (2015) GAR22β regulates cell migration, sperm motility and axoneme structure. Molecular Biology of the Cell 27: 277-294. DOI: 10.1091/mbc.E15-06-0426

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