Prof. Dr. Marc Spehr

Principal Investigator

Fields of Research:
Neurophysiology and Reproductive Physiology

Electrophysiology, Life-Cell Imaging, Histology, Confocal Microscopy

Tel.: 0241 / 80-20802
Fax: 0241 / 80-22133

Curriculum Vitae

Selected Publications:

Christoph Hamacher, Rudolf Degen, Melissa Franke, Victoria K. Switacz, David Fleck, Raghu Ram Katreddi, Andres Hernandez-Clavijo, Martin Strauch, Nao Horio, Enno Hachgenei, Jennifer Spehr, Stephen D. Liberles, Dorit Merhof, Paolo E. Forni, Geraldine Zimmer-Bensch, Yoram Ben-Shaul, and Marc Spehr (2024) A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling, Current Biology 34,
Victoria K Switacz, Sarah K. Wypysek, Rudolf Degen, Jérôme J. Crassous, Marc Spehr and Walter Richtering (2020) Influence of Size and Cross-Linking Density of Microgels on Cellular Uptake and Uptake Kinetics. Biomacromolecules. DOI:
Ardila-Fierro KJ, Pich A, Spehr M, Hernández JG, Bolm C (2019) Synthesis of acylglycerol derivatives by mechanochemistry. Beilstein Journal of Organic Chemistry, 15, 811–817. DOI: 10.3762/bjoc.15.78
Marom K, Horesh N, Abu-Snieneh A, Dafni A, Paul R, Fleck D, Spehr M, Ben-Shau Yl (2019) The vomeronasal system can mediate novel stimulus response pairings. Cell Reports. DOI:10.1016/j.celrep.2019.03.042
Gretenkord S, Kostka JK, Hartung H, Watznauer K, Fleck D, Minier-Toribio A, Spehr M, Hanganu-Opatz IL (2019) Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice. PLoS Biology 17: e2006994. DOI: 10.1371/journal.pbio.2006994
Wong WM, Nagel M, Hernandez-Clavijo A, Pifferi S, Menini A§ , Spehr M§, Meeks JP§ (2018) Sensory Adaptation to Chemical Cues by Vomeronasal Sensory Neurons. eNeuro. DOI: 10.1523/ENEURO.0223-18.2018
§shared senior authorship 
Mundt N, Spehr M, Lishko PV (2018) TRPV4 is the temperature-sensitive ion channel of human sperm. eLIFE 7: e35853. DOI: 10.7554/eLife.35853
Mohrhardt J, Nagel M, Fleck D, Ben-Shaul Y, Spehr M (2018) Signal detection and coding in the accessory olfactory system. Chemical Senses 43: 667-695. DOI: 10.1093/chemse/bjy061
Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A. ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation. Scientific Reports 8: 1431. DOI: 10.1038/s41598-018-19624-3
Pelz T, Drose DR, Fleck D, Henkel B, Ackels T, Spehr M, Neuhaus EM (2018) An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase. PLOS ONE 13:e0191219. DOI: 10.1371/journal.pone.0191219
Unger J, Mansour M, Kopazka M, Gronloh N, Spehr M, Merhof D. (2017) An Unsupervised Learning Approach for Tracking Mice in an Enclosed Area. BMC Bioinformatics 18(1): 272. DOI: 10.1186/s12859-017-1681-1
Wallbrecher R⁠, Ackels T, Olea⁠ RA, Klein MJ, Caillon⁠ L, Schiller⁠ J, Bove-Geurts PH, van Kuppevelt⁠ TH, Ulrich⁠ AS, Spehr⁠ M, Adjobo-Hermans⁠ MJW, Brock R. (2017) Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity. Journal of Controlled Release 256: 68–78.DOI: 10.1016/j.jconrel.2017.04.013
Henkel B, Bintig W, Bhat S, Spehr M, Neuhaus EM (2016) NHERF1 in Microvilli of Vomeronasal Sensory Neurons. Chemical Senses 42: 25-35.144. DOI: 10.1093/chemse/bjw094
Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M(2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271.
Gorin M*, Tsitoura C*, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O’Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M(2016) Interdependent conductances drive infra-slow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons. The Journal of Neuroscience 36: 3127-3144.
Cichy A, Ackels T, Tsitoura C, Kahan A, Gronloh N, Söchtig M, Engelhardt C, Ben-Shaul Y, Müller F, Spehr J and Spehr M (2015). HCN channels mediate proton-dependent signaling in the mouse vomeronasal organ. The Journal of Neuroscience 35: 4025-4039. 
Henkel B, Drose D, Ackels T, Oberland S, Spehr M and Neuhaus EM (2014). Coexpression of Anoctamins in cilia of olfactory sensory neurons. Chemical Senses 40: 73-87.
Kaur AW, Ackels T, Kuo T-H, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M, Stowers L (2014) Murine Pheromone Proteins Constitute a Context-Dependent Combinatorial Code Governing Multiple Social Behaviors. Cell 157, 676–688.
Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD (2013) A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system. Nature 502: 368-371.
Fluegge D, Moeller LM, Cichy A, Gorin M, Weth A, Veitinger S, Cainarca S, Lohmer S, Corrazza S, Neuhaus EM, Baumgartner W, Spehr J, Spehr M (2012) Mitochondrial Ca2+ Mobilization is a key element in olfactory signaling. Nat. Neurosci. 15: 754-762.
Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corrazza S, Spehr J, Neuhaus EM, Spehr M (2011) Mitochondrial Ca2+ Mobilization in Purinergic Mouse Sertoli Cell Signaling. J. Physiol. 589: 5033–5055.
Ferrero DM, Lemon JK, FlueggeD, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. PNAS 108: 11235-11240.
Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009) Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459: 574-577.
Spehr M and Munger SD (2009) Olfactory receptors: GPCRs and beyond. J. Neurochem. 109: 1570-1583. 
Hagendorf S, Fluegge D, Engelhardt C, Spehr M (2009). Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. J. Neurosci. 29: 206-221. 
Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F (2006) Essential role of the main olfactory system in social recognition of MHC class I peptides. J. Neurosci. 26: 1961-1970. 
Kelliher KR§Spehr M§, Leinders-Zufall T, Zufall F (2006) Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur. J. Neurosci. 23: 3385-3390.                    § authors contributed equally 
Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H (2004) Dual capacity of a human olfactory receptor. Current Biology 14: 832-833.
Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J. Biol. Chem. 279: 40194-40203.
Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058.
Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. J. Neurosci. 22: 8429-8437.  
Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-773.