Position:
Principal Investigator
Fields of Research:
Neurophysiology and Reproductive Physiology
Methods:
Electrophysiology, Life-Cell Imaging, Histology, Confocal Microscopy
Contact:
m.spehr@sensorik.rwth-aachen.de
Tel.: 0241 / 80-20802
Fax: 0241 / 80-22133
ResearchGate
Curriculum Vitae
Selected Publications:
| Christoph Hamacher, Rudolf Degen, Melissa Franke, Victoria K. Switacz, David Fleck, Raghu Ram Katreddi, Andres Hernandez-Clavijo, Martin Strauch, Nao Horio, Enno Hachgenei, Jennifer Spehr, Stephen D. Liberles, Dorit Merhof, Paolo E. Forni, Geraldine Zimmer-Bensch, Yoram Ben-Shaul, and Marc Spehr (2024) A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling, Current Biology 34, https://doi.org/10.1016/j.cub.2024.01.036 | |
| Victoria K Switacz, Sarah K. Wypysek, Rudolf Degen, Jérôme J. Crassous, Marc Spehr and Walter Richtering (2020) Influence of Size and Cross-Linking Density of Microgels on Cellular Uptake and Uptake Kinetics. Biomacromolecules. DOI: https://doi.org/10.1021/acs.biomac.0c00478 | |
| Ardila-Fierro KJ, Pich A, Spehr M, Hernández JG, Bolm C (2019) Synthesis of acylglycerol derivatives by mechanochemistry. Beilstein Journal of Organic Chemistry, 15, 811–817. DOI: 10.3762/bjoc.15.78 | |
| Marom K, Horesh N, Abu-Snieneh A, Dafni A, Paul R, Fleck D, Spehr M, Ben-Shau Yl (2019) The vomeronasal system can mediate novel stimulus response pairings. Cell Reports. DOI:10.1016/j.celrep.2019.03.042 | |
| Gretenkord S, Kostka JK, Hartung H, Watznauer K, Fleck D, Minier-Toribio A, Spehr M, Hanganu-Opatz IL (2019) Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice. PLoS Biology 17: e2006994. DOI: 10.1371/journal.pbio.2006994 | |
| Wong WM, Nagel M, Hernandez-Clavijo A, Pifferi S, Menini A§ , Spehr M§, Meeks JP§ (2018) Sensory Adaptation to Chemical Cues by Vomeronasal Sensory Neurons. eNeuro. DOI: 10.1523/ENEURO.0223-18.2018 §shared senior authorship | |
| Mundt N, Spehr M, Lishko PV (2018) TRPV4 is the temperature-sensitive ion channel of human sperm. eLIFE 7: e35853. DOI: 10.7554/eLife.35853 | |
| Mohrhardt J, Nagel M, Fleck D, Ben-Shaul Y, Spehr M (2018) Signal detection and coding in the accessory olfactory system. Chemical Senses 43: 667-695. DOI: 10.1093/chemse/bjy061 | |
| Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A. ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation. Scientific Reports 8: 1431. DOI: 10.1038/s41598-018-19624-3 | |
| Pelz T, Drose DR, Fleck D, Henkel B, Ackels T, Spehr M, Neuhaus EM (2018) An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase. PLOS ONE 13:e0191219. DOI: 10.1371/journal.pone.0191219 | |
| Unger J, Mansour M, Kopazka M, Gronloh N, Spehr M, Merhof D. (2017) An Unsupervised Learning Approach for Tracking Mice in an Enclosed Area. BMC Bioinformatics 18(1): 272. DOI: 10.1186/s12859-017-1681-1 | |
| Wallbrecher R, Ackels T, Olea RA, Klein MJ, Caillon L, Schiller J, Bove-Geurts PH, van Kuppevelt TH, Ulrich AS, Spehr M, Adjobo-Hermans MJW, Brock R. (2017) Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity. Journal of Controlled Release 256: 68–78.DOI: 10.1016/j.jconrel.2017.04.013 | |
| Henkel B, Bintig W, Bhat S, Spehr M, Neuhaus EM (2016) NHERF1 in Microvilli of Vomeronasal Sensory Neurons. Chemical Senses 42: 25-35.144. DOI: 10.1093/chemse/bjw094 | |
| Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M(2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271. | |
| Gorin M*, Tsitoura C*, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O’Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M(2016) Interdependent conductances drive infra-slow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons. The Journal of Neuroscience 36: 3127-3144. | |
| Cichy A, Ackels T, Tsitoura C, Kahan A, Gronloh N, Söchtig M, Engelhardt C, Ben-Shaul Y, Müller F, Spehr J and Spehr M (2015). HCN channels mediate proton-dependent signaling in the mouse vomeronasal organ. The Journal of Neuroscience 35: 4025-4039. | |
| Henkel B, Drose D, Ackels T, Oberland S, Spehr M and Neuhaus EM (2014). Coexpression of Anoctamins in cilia of olfactory sensory neurons. Chemical Senses 40: 73-87. | |
| Kaur AW, Ackels T, Kuo T-H, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M, Stowers L (2014) Murine Pheromone Proteins Constitute a Context-Dependent Combinatorial Code Governing Multiple Social Behaviors. Cell 157, 676–688. | |
| Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD (2013) A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system. Nature 502: 368-371. | |
| Fluegge D, Moeller LM, Cichy A, Gorin M, Weth A, Veitinger S, Cainarca S, Lohmer S, Corrazza S, Neuhaus EM, Baumgartner W, Spehr J, Spehr M (2012) Mitochondrial Ca2+ Mobilization is a key element in olfactory signaling. Nat. Neurosci. 15: 754-762. | |
| Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corrazza S, Spehr J, Neuhaus EM, Spehr M (2011) Mitochondrial Ca2+ Mobilization in Purinergic Mouse Sertoli Cell Signaling. J. Physiol. 589: 5033–5055. | |
| Ferrero DM, Lemon JK, FlueggeD, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. PNAS 108: 11235-11240. | |
| Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009) Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459: 574-577. | |
| Spehr M and Munger SD (2009) Olfactory receptors: GPCRs and beyond. J. Neurochem. 109: 1570-1583. | |
| Hagendorf S, Fluegge D, Engelhardt C, Spehr M (2009). Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. J. Neurosci. 29: 206-221. | |
| Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F (2006) Essential role of the main olfactory system in social recognition of MHC class I peptides. J. Neurosci. 26: 1961-1970. | |
| Kelliher KR§, Spehr M§, Leinders-Zufall T, Zufall F (2006) Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur. J. Neurosci. 23: 3385-3390. § authors contributed equally | |
| Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H (2004) Dual capacity of a human olfactory receptor. Current Biology 14: 832-833. | |
| Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J. Biol. Chem. 279: 40194-40203. | |
| Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058. | |
| Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. J. Neurosci. 22: 8429-8437. | |
| Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-773. |
