News from SSR 2019

July 21, 2019

On the Annual Meeting of the Society for the Study of Reproduction (SSR) 2019 in San Jose, California, USA, Dr. David Fleck, Nadine Mundt and Lina Kenzler will present their respective data in oral presentations. Justine Fischoeder will present her data on posters and in a flash talk.

Justine was awarded a Travel Grant from the Male Contraceptive Initiative (MCI), Nadine and Lina each won an Best International Abstract Award.

Nadine won an SSR trainee-travel Award, Lina was awarded the Lalor Foundation Merit Award.

New Publication by Sebastian Malinowski

July 20, 2019

Malinowski S, Wolf J, Kuenzel T (2019) Intrinsic and Synaptic Dynamics Contribute to Adaptation in the Core of the Avian Central Nucleus of the Inferior Colliculus. Frontiers in Neural Circuits 13.

Abstract: The reduction of neuronal responses to repeated stimulus presentation occurs in many sensory neurons, also in the inferior colliculus of birds. The cellular mechanisms that cause response adaptation are not well described. Adaptation must be explicable by changes in the activity of input neurons, short-term synaptic plasticity of the incoming connections, excitability changes of the neuron under consideration or influences of inhibitory or modulatory network connections. Using whole-cell recordings in acute brain slices of the embryonic chicken brain we wanted to understand the intrinsic and synaptic contributions to adaptation in the core of the central nucleus of the inferior colliculus (ICCc). We described two neuron types in the chicken ICCc based on their action potential firing patterns: Phasic/onset neurons showed strong intrinsic adaptation but recovered more rapidly. Tonic/sustained firing neurons had weaker adaptation but often had additional slow components of recovery from adaptation. Morphological analysis suggested two neuron classes, but no physiological parameter aligned with this classification. Chicken ICCc neurons received mostly mixed AMPA- and NMDA-type glutamatergic synaptic inputs. In the majority of ICCc neurons the input synapses underwent short-term depression. With a simulation of the putative population output activity of the chicken ICCc we showed that the different adaptation profiles of the neuron classes could shift the emphasize of stimulus encoding from transients at long intervals to ongoing parts at short intervals. Thus, we report here that description of biophysical and synaptic properties can help to explain adaptive phenomena in central auditory neurons.

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