2024
Nagel M, Niestroj M, Bansal R, Fleck D, Lampert A, Stopkova R, Stopka P, Ben-Shaul Y, Spehr M. Deciphering the chemical language of inbred and wild mouse conspecific scents. Elife. 2024 May 15;12:RP90529. doi: 10.7554/eLife.90529. PMID: 38747258; PMCID: PMC11095937.
Röhr AK, Kohn N, Bergs R, Clemens B, Lampert A, Spehr M, Habel U, Wagels L. Increased anger and stress and heightened connectivity between IFG and vmPFC in victims during social interaction. Sci Rep. 2024 Apr 11;14(1):8471. doi: 10.1038/s41598-024-57585-y. PMID: 38605132; PMCID: PMC11009292.
Hamacher C, Degen R, Franke M, Switacz VK, Fleck D, Katreddi RR, Hernandez-Clavijo A, Strauch M, Horio N, Hachgenei E, Spehr J, Liberles SD, Merhof D, Forni PE, Zimmer-Bensch G, Ben-Shaul Y, Spehr M. A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling. Curr Biol. 2024 Mar 25;34(6):1206-1221.e6. doi: 10.1016/j.cub.2024.01.036. Epub 2024 Feb 5. PMID: 38320553; PMCID: PMC10965388.
Scheliga S, Dohrn MF, Habel U, Lampert A, Rolke R, Lischka A, van den Braak N, Spehr M, Jo HG, Kellermann T. Reduced Gray Matter Volume and Cortical Thickness in Patients With Small-Fiber Neuropathy. J Pain. 2024 Jan 10:104457. doi: 10.1016/j.jpain.2024.01.001. Epub ahead of print. PMID: 38211845.
2023
Cohen O, Kahan A, Steinberg I, Malinowski ST, Rokni D, Spehr M, Ben-Shaul Y. Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb. J Neurosci. 2023 Dec 13;43(50):8700-8722. doi: 10.1523/JNEUROSCI.1055-23.2023. PMID: 37903594; PMCID: PMC10727196.
Dellin M, Rohrbeck I, Asrani P, Schreiber JA, Ritter N, Glorius F, Wünsch B, Budde T, Temme L, Strünker T, Stallmeyer B, Tüttelmann F, Meuth SG, Spehr M, Matschke J, Steinbicker A, Gatsogiannis C, Stoll R, Strutz-Seebohm N, Seebohm G. The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. Biol Chem. 2023 Feb 23;404(4):241-254. doi: 10.1515/hsz-2022-0247. PMID: 36809224.
2022
Scheliga S, Kellermann T, Lampert A, Rolke R, Spehr M, Habel U. Neural correlates of multisensory integration in the human brain: an ALE meta-analysis. Rev Neurosci. 2022 Sep 12;34(2):223-245. doi: 10.1515/revneuro-2022-0065. PMID: 36084305.
Asgharpour S, Chi LA, Spehr M, Carloni P, Alfonso-Prieto M. Fluoride Transport and Inhibition Across CLC Transporters. Handb Exp Pharmacol. 2024;283:81-100. doi: 10.1007/164_2022_593. Erratum in: Handb Exp Pharmacol. 2022 Dec 10;: PMID: 36042142.
Mundt N, Kenzler L, Spehr M (2022) Purinergic Signaling in Spermatogenesis. Front Endocrinol 2022;13:1–7. DOI: https://doi.org/10.3389/fendo.2022.867011
Song L, Xu X, Putthoff P, Fleck D, Spehr M, Hanganu-Opatz IL (2022) Sparser and less efficient hippocampal-prefrontal projections account for developmental network dysfunction in a model of psychiatric risk mediated by gene-environment interaction. The Journal of Neuroscience 42: 601–618. DOI: https://doi.org/10.1523/JNEUROSCI.1203-21.2021
2021
Bansal R, Nagel M, Stopkova R, Sofer Y, Kimchi T, Stopka P, Spehr M, Ben-Shaul Y (2021) Do all mice smell the same? Analysis of accessory olfactory bulb responses of male mice from two inbred mouse strains to urine stimuli from inbred and wild male and female mice. BMC Biology 19: 133. DOI: https://doi.org/10.1186/s12915-021-01064-7
Hernandez-Clavijo A, Sarno N, Gonzalez-Velandia K, Degen R, Fleck D, Rock J, Spehr M, Menini A, Pifferi S (2021) TMEM16A and TMEM16B modulate pheromone-evoked action potential firing in mouse vomeronasal sensory neurons. eNeuro 8 (5): ENEURO.0179-21.2021 1-15. DOI: https://doi.org/10.1523/ENEURO.0179-21.2021
Heinrichs B, Liu B, Zhang J, Meents JE, Le K, Erickson A, Hautvast P, Zhu X, Li N, Liu Y, Spehr M, Habel U, Rothermel M, Namer B, Zhang X, Lampert A, Duan G (2021) The potential effect of Nav1.8 in autism spectrum disorder: Evidence from a congenital case with compound heterozygous SCN10A mutations. Frontiers in Molecular Neuroscience 14: 709228. DOI: https://doi.org/10.3389/fnmol.2021.709228
Bachmann S, Linde J, Bell M, Spehr M, Zempel H, Zimmer-Bensch G (2021) DNA methyltransferase 1 (DNMT1) shapes neuronal activity of 2 human iPSC-derived glutamatergic cortical neurons. International Journal of Molecular Sciences 22: 2034. DOI: https://doi.org/10.3390/ijms22042034
Zhang Y, Vargas Cifuentes L, Wright K, Bhattarai J, Mohrhardt J, Fleck D, Janke E, Jiang C, Cranfill S, Goldstein N, chreck M, Moberly A, Yu Y, Arenkiel B, Betley J, Luo W, Stegmaier J, Wesson D, Spehr M, Fuccillo M, Ma M (2021) Ventral striatal islands of Calleja neurons control grooming in mice. Nature Neuroscience 24 (12). DOI: 10.1038/s41593-021-00952-z
David Fleck, Lina Kenzler, Nadine Mundt, Martin Strauch, Naofumi Uesaka, Robert Moosmann, Felicitas Bruentgens, Annika Missel, Artur Mayerhofer, Dorit Merhof, Jennifer Spehr, Marc Spehr (2021) ATP activation of peritubular cells drives testicular sperm transport. eLife 2021;10:e62885.
DOI: https://doi.org/10.7554/eLife.62885
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2020
Kostka JK, Gretenkord S, Spehr M, Hanganu-Opatz IL (2020) Bursting mitral cells time the oscillatory coupling between olfactory bulb and entorhinal networks in neonatal mice. The Journal of Physiology 598: 5753–5769. DOI: https://doi.org/10.1113/jp280131
Hahn A, Pensold D, Bayer C, Tittelmeier J, Gonzalez-Bermudez L, Marx-Blümel L, Linde J, Groß J, Salinas-Riester G, Lingner T, von Maltzahn J, Spehr M, Pieler T, Urbach A, Zimmer-Bensch G (2020) DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons. Frontiers Cell and Developmental Biology 8: 639. DOI: https://doi.org/10.3389/fcell.2020.00639
Victoria K Switacz, Sarah K. Wypysek, Rudolf Degen, Jérôme J. Crassous, Marc Spehr and Walter Richtering (2020) Influence of Size and Cross-Linking Density of Microgels on Cellular Uptake and Uptake Kinetics. Biomacromolecules. DOI: https://doi.org/10.1021/acs.biomac.0c00478
Chryssanthi Tsitoura, Sebastian T. Malinowski, Julia Mohrhardt, Rudolf Degen, Brett T. DiBenedictis, Yuan Gao, Katja Watznauer, Kira Gerhold, Maximilian Nagel, Monika Weber, Markus Rothermel, Ileana L. Hanganu-Opatz, Yoram Ben-Shaul, Ian G. Davison and Marc Spehr (2020) Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits. Journal of Neuroscience 40 (21). DOI: https://doi.org/10.1523/JNEUROSCI.2925-19.2020
2019
Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Boehner A, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ (2019) Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis. Kidney International 96: 505-516. DOI: https://doi.org/10.1016/j.kint.2019.02.034
Malinowski S, Wolf J, Kuenzel T (2019) Intrinsic and Synaptic Dynamics Contribute to Adaptation in the Core of the Avian Central Nucleus of the Inferior Colliculus. Frontiers in Neural Circuits 13. DOI: https://doi.org/10.3389/fncir.2019.00046
Ardila-Fierro KJ, Pich A, Spehr M, Hernández JG, Bolm C (2019) Synthesis of acylglycerol derivatives by mechanochemistry. Beilstein Journal of Organic Chemistry, 15, 811–817. DOI: 10.3762/bjoc.15.78
Marom K, Horesh N, Abu-Snieneh A, Dafni A, Paul R, Fleck D, Spehr M, Ben-Shau Yl (2019) The vomeronasal system can mediate novel stimulus response pairings. Cell Reports. DOI:10.1016/j.celrep.2019.03.042
Gretenkord S, Kostka JK, Hartung H, Watznauer K, Fleck D, Minier-Toribio A, Spehr M, Hanganu-Opatz IL (2019) Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice. PLoS Biology 17: e2006994. DOI: 10.1371/journal.pbio.2006994
2018
Wong WM, Nagel M, Hernandez-Clavijo A, Pifferi S, Menini A§ , Spehr M§, Meeks JP§ (2018) Sensory Adaptation to Chemical Cues by Vomeronasal Sensory Neurons. eNeuro. DOI: 10.1523/ENEURO.0223-18.2018
§shared senior authorship
Mundt N, Spehr M, Lishko PV (2018) TRPV4 is the temperature-sensitive ion channel of human sperm. eLIFE 7: e35853. DOI: 10.7554/eLife.35853
Mohrhardt J, Nagel M, Fleck D, Ben-Shaul Y, Spehr M (2018) Signal detection and coding in the accessory olfactory system. Chemical Senses 43: 667-695. DOI: 10.1093/chemse/bjy061
Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A. ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation. Scientific Reports 8: 1431. DOI: 10.1038/s41598-018-19624-3
Pelz T, Drose DR, Fleck D, Henkel B, Ackels T, Spehr M, Neuhaus EM (2018) An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase. PLOS ONE 13:e0191219. DOI: 10.1371/journal.pone.0191219
2017
Unger J, Mansour M, Kopazka M, Gronloh N, Spehr M, Merhof D. (2017) An Unsupervised Learning Approach for Tracking Mice in an Enclosed Area. BMC Bioinformatics 18(1): 272. DOI: 10.1186/s12859-017-1681-1
Wallbrecher R, Ackels T, Olea RA, Klein MJ, Caillon L, Schiller J, Bove-Geurts PH, van Kuppevelt TH, Ulrich AS, Spehr M, Adjobo-Hermans MJW, Brock R. (2017) Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity. Journal of Controlled Release 256: 68–78.DOI: 10.1016/j.jconrel.2017.04.013
Henkel B, Bintig W, Bhat S, Spehr M, Neuhaus EM (2016) NHERF1 in Microvilli of Vomeronasal Sensory Neurons. Chemical Senses 42: 25-35.144. DOI: 10.1093/chemse/bjw094
2016
Gorin M, Tsitoura C, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O’Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M (2016) Interdependent conductances drive infra-slow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons. The Journal of Neuroscience 36: 3127-3144. DOI: 10.1523/JNEUROSCI.2520-15.2016
Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M (2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271. DOI: 10.1085/jgp.201611636
2015
Cichy A, Ackels T, Tsitoura C, Kahan A, Gronloh N, Söchtig M, Engelhardt CH, Ben-Shaul Y, Müller F, Spehr J, Spehr M (2015) Extracellular pH regulates excitability of vomeronasal sensory neurons. The Journal of Neuroscience 35: 4025-4039. DOI: 10.1523/JNEUROSCI.2593-14.2015
Bitzenhofer SH, Sieben K, Siebert KD, Spehr M, Hanganu-Opatz IL (2015) Oscillatory activity in developing prefrontal networks results from theta-gamma modulated synaptic inputs. Cell Reports 3: 486-497. DOI: 10.1016/j.celrep.2015.03.031
Henkel B, Drose D, Ackels T, Oberland S, Spehr M, Neuhaus EM (2014) Coexpression of Anoctamins in cilia of olfactory sensory neurons. Chemical Senses 40: 73-87. DOI: 10.1093/chemse/bju061
Oberland S, Ackels T, Gaab S, Pelz T, Spehr J, Spehr M, Neuhaus EM (2015) CD36 is involved in oleic acid detection by the murine olfactory system. Frontiers in Cellular Neuroscience9: 366. DOI: 10.3389/fncel.2015.00366
2014
Kaur AW, Ackels T, Kuo T, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M and Stowers L (2014) Murine Pheromone Proteins Constitute a Context-Dependent Combinatorial Code Governing Multiple Social Behaviors. Cell 157: 676-88. DOI: 10.1016/j.cell.2014.02.025
Ackels T, von der Weid B, Rodriguez I and Spehr M (2014)
Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ. Frontiers in Neuroanatomy. DOI: 10.3389/fnana.2014.00134
2012 – 2013
Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD (2013) A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system. Nature, DOI: 10.1038/nature12579
Dietzel E, Wessling J, Floehr J, Schäfer C, Ensslen S, Denecke B, Rösing B, Neulen J, Veitinger T, Spehr M, Tropartz T, Tolba R, Renne R, Egert A, Schorle H, Gottenbusch Y, Hildebrand A, Yiallouros I, Stöcker W, Weiskirchen R, Jahnen-Dechent W (2013) Fetuin-B, a liver-derived plasma protein is essential for fertilization. Developmental Cell 25, 106–112. DOI: 10.1016/j.devcel.2013.03.001
Fluegge D, Moeller LM, Cichy A, Gorin M, Weth A, Veitinger S, Cainarca S, Lohmer S, Corrazza S, Neuhaus EM, Baumgartner W, Spehr J, Spehr M (2012) Mitochondrial Ca Mobilization is a key element in olfactory signaling. Nature Neuroscience 15: 754-762. DOI: 10.1038/nn.3074
2011
Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M, Neuhaus EM (2011) G-protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. Journal of Biological Chemistry 286: 13184-13192. DOI: 10.1074/jbc.M110.183525
Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK§, Spehr M§, Hatt H§. (2011) Chemosensory
Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. Journal of Biological Chemistry 286: 17311-17325. DOI: 10.1074/jbc.M110.211524
§shared senior authorship
Ferrero DM, Lemon JK, FlueggeD, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. Proceedings of the National Academy of Sciences 108: 11235-11240. DOI: 10.1073/pnas.1103317108
Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corrazza S, Spehr J, Neuhaus EM, Spehr M (2011) Mitochondrial Ca Mobilization in Purinergic Mouse Sertoli Cell Signaling. The Journal of Physiology589: 5033–5055. DOI: 10.1113/jphysiol.2011.216309
2009 – 2010
Hagendorf S, Fluegge D, Engelhardt C, Spehr M (2009). Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. The Journal of Neuroscience 29: 206-221. DOI: 10.1523/JNEUROSCI.3656-08.2009
Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders-Zufall T, Zufall F (2009) Ca2+-calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. The Journal of Neuroscience 29:2125-2135. DOI: 10.1523/JNEUROSCI.5416-08.2009
Spehr M and Munger SD (2009) Olfactory receptors: GPCRs and beyond. The Journal of Neurochemistry 109: 1570-1583. DOI: 10.1111/j.1471-4159.2009.06085.x
Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009) Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459: 574-577. DOI: 10.1038/nature08029
2006 – 2008
Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006) β-arrestin2-mediated internalization of mammalian odorant receptors. The Journal of Neuroscience 26: 9902-9912. DOI: 10.1523/JNEUROSCI.2897-06.2006
Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F (2006) Essential role of the main olfactory system in social recognition of MHC class I peptides. The Journal of Neuroscience 26: 1961-1970. DOI: 10.1523/JNEUROSCI.4939-05.2006
Kelliher KR§, Spehr M§, Leinders-Zufall T, Zufall F (2006) Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. European Journal of Neuroscience 23: 3385-3390. DOI: 10.1111/j.1460-9568.2006.04866.x
§ authors contributed equally
2001 – 2005
Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-773. DOI: 10.1016/S0896-6273(02)00610-4
Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. The Journal of Neuroscience 22: 8429-8437. DOI: 10.1523/JNEUROSCI.22-19-08429.2002
Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058. DOI: 10.1126/science.1080376
Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. Journal of Biological Chemistry 279: 40194-40203. DOI: 10.1074/jbc.M403913200
Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H (2004) Dual capacity of a human olfactory receptor. Current Biology 14: 832-833. DOI: 10.1016/j.cub.2004.09.034
