Using state-of-the-art physiological recording methods, we investigate signaling cascades in living cells. In our laboratory, several microscopy setups allow both patch-clamp recordings and live-cell imaging analysis (confocal and widefield fluorescence microscopy).
Each modular system currently consists of upright or inverted Leica microscopes, EPC10 patch-clamp amplifiers (HEKA), and micromanipulator units manufactured by Luigs & Neumann.
To study fast cellular processes in acute tissue slices, we use a multi-beam confocal imaging scanner (VT-HAWK) built by Visitech Int. Fast synchronization between scanner and an EMCCD camera allows frame rates ≥500 Hz.
In addition, group members benefit from fully equipped molecular, biochemistry, and histology laboratories.